for the induction of interferon production), as well as for radio diagnostic purpose (indium‐111). ![]() Among the drugs proposed to be encapsulated in liposomes, remarkable are drugs used in anti‐fungal therapy (amphotericin B, nystatin, econazole), in anticancer therapy (doxorubicine, daunorubicin, methotrexate (MTX), cytarabine, vincristine, paclitaxel, mitoxantrone), in the treatment of asthma (albuterol) and in the treatment of some inflammatory diseases (clodronate, methotrexate, lactoferrin), in anti‐viral therapy (e.g. Liposomes have been proposed as drug vector systems in the treatment of many diseases. Given that the encapsulating of the drug in vector systems may result in the increasing concentration at the site of action, the methotrexate liposomes represent a targeted therapy with an optimized therapeutic efficacy-risk toxicity ratio. The methotrexate liposomes exhibited significant anti‐inflammatory activity and showed reduced toxicity. The cellular activation is probably the main target of the drug and not the neoplastic proliferation of cells. Methotrexate incorporated into liposomes moderately reduces the proliferation of K562 cells, but significantly inhibits RNA synthesis. The effect of methotrexate incorporated in liposomes has been investigated in vitro on human lymphoblastic cell line K562. The liposomes were characterized in terms of structure, size, degree of poly‐dispersion and encapsulation efficiency. Liposomes with methotrexate as such, as well as its disodium salt, were prepared using two methods. Its side effects have led researchers to direct their efforts to reduce toxicity, while maintaining efficacy of methotrexate. ![]() Methotrexate, a folate antagonist, was originally developed as an antineoplastic agent and subsequently used in inflammatory and/or immunosuppressive diseases. The following characteristics recommend the liposomes as attractive candidates for drug transportation: solubilisation, duration of action, targeting potential and internalisation. Liposomes were proposed as drug vector systems in the treatment of many diseases.
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